Search databaseBooksAll DatabasesAssemblyBiocollectionsBioProjectBioSampleBioSystemsBooksClinVarConserved DomainsdbGaPdbVarGeneGenomeGEO DataSetsGEO ProfilesGTRHomoloGeneIdentical Protein Internet CatalogNucleotideOMIMPMCPopSetProteinProtein ClustersProtein Family ModelsPubChem BioAssayPubChem CompoundPubChem SubstancePubMedSNPSRAStructureTaxonomyToolKitToolKitAllToolKitBookgh Bookshelf. A service of the National Library of Medicine, National Institutes of Health.

You are watching: When a substance dissolves in water, heat energy is released if:

StatPearls . Treasure Island also (FL): StatPearls Publishing; 2021 Jan-.



Dissolution <1><2><3>

Dissolution is the procedure where a solute in gaseous, liquid, or solid phase dissolves in a solvent to develop a solution.


Solubility is the maximum concentration of a solute that deserve to disresolve in a solvent at a offered temperature. At the maximum concentration of solute, the solution is shelp to be saturated. The devices of solubility deserve to be offered in mol/L or g/L.

Factors that impact solubility include: 



The rate of dissolution is represented by the Noyes-Whitney equation: dm/dt = D*A*(Cs - C)/h




Effect of temperature on liquid and solid solutes

As temperature rises, the solubility of a solid or liquid can fluctuate depending on whether the dissolution reactivity is exothermic or endothermic.

Increasing solubility via increasing temperature

In endothermic dissolution reactions, the net energy from breaking and also developing bonds outcomes in heat power being took in into the system as the solute dissolves. When the temperature of the device increases, additional head energy is presented into the mechanism.
So according to Le Chatelier’s Principle, the device will adjust to this increase in the heat by cultivating the dissolution reactivity to absorb the added warm power. Increasing the temperature will therefore rise the solubility of the solute.
An example of a solute whose solubility rises with higher temperature is ammonium nitprice, which deserve to be used in first-aid cold packs. Ammonium nitprice disfixing in solution is an endothermic reaction. As the ammonium nitrate dissolves, warm power is absorbed from the environment causing the bordering setting to feel cold.
In exothermic reactions, warmth energy is released as soon as the solute dissolves in a solution. Increasing temperature introduces even more warm right into the mechanism. Following Le Chatelier’s Principle, the device will adjust to this excess heat power by inhibiting the dissolution reaction. Increasing temperature, therefore, decreases the solubility of the solute. 
An example of a solute that decreases in solubility with boosting temperature is calcium hydroxide, which have the right to be provided to treat chemical burns and as an antacid.

Effect of temperature on gas solutes

In basic, warmth power is released as gas dissolves in solution, definition the dissolution reactivity is exothermic. Therefore, a gas becomes less soluble as tempeprice increases.

Increasing temperature outcomes in raised kinetic power. Gas molecules via greater kinetic energy move even more swiftly bring about the intermolecular bonds in between the gas solute and also solvent breaking. 

Pressure: Henry’s law

The solubility of gas is affected by transforms in push on the system. A gas dissolves in liquids to develop services. This outcomes in equilibrium in the device wbelow a propercent of gas molecules is liquified in liquid while the rest stays in gaseous phase over the liquid.

Henry’s law says that: “At consistent temperature, the amount of gas that dissolves in a volume of liquid is proportional to the partial press of the gas in equilibrium via the liquid.”

Henry"s legislation results in the following equation: C = kP


C represents the solubility of the gas at a certain temperature in a details solvent
K represents Henry’s law constant
P represents the partial press of the gas i.e. the press the gas exerts on the device at a provided volume and also temperature

Hence as the push of the gas above the liquid in the device rises, the gas molecules become more soluble in the solvent. Likewise, if the push of the gas in the device decreases, gas becomes much less soluble in the solvent.

Issues of Concern

Limitations of Henry’s Law on gas solubility:

Only applies if the gas molecules are in equilibrium
Does not apply if tbelow is a chemical reactivity between the solvent and the solute


Solubility <7><8><9>

Le Chatelier’s principle:

If stressors prefer push and warmth are applied to the equilibrium, the device will respond by adjusting to minimize the impacts of the stress and anxiety.

For instance, if press is applied to a device, the dissolution reactivity will certainly respond to minimize this stress by reducing the press in the mechanism.

Heat of solution

Solids and liquids develop as a result of individual particles being held together by inter-particulate bonds. To form a solution, energy is compelled to break the bonds in between the pposts within the solid or liquid. Heat power is additionally forced to break the bonds in a solvent to insert one of the molecules into the solution. Both of these procedures are endothermic. Heat power is released once the solute molecules develop bonds with the solvent molecules i.e. this process is exothermic.

Depending on whether even more power is used to break the bonds within the solute and solvent or is released when brand-new bonds are formed in between the solute and also solvent, the reaction as a whole have the right to be exothermic or endothermic.

If even more energy is compelled to break the bonds within the solute and also solvent than is released once brand-new bonds are created in between the solute and solvent, the reaction is taken into consideration endothermic.
If even more power is released when new bonds are developed in between the solute and solvent than is compelled to break the bonds within the solute and solvent, the reactivity is thought about exothermic.

The total amount of warm energy released from or absorbed by the mechanism = sum of warm energy soaked up once bonds are damaged – the amount of warm power released when bonds are formed

If the total amount of heat power released/soaked up from the device is higher than zero, the reactivity is endothermic.
If the full amount of warmth power released/absorbed from the system is much less than zero, the reaction is exothermic.


Application of Henry’s Law: Decompression Sickness

Henry’s Law explains the sensations of decompression sickness. When scuba divers submerge themselves in deep water, the pressure of the water rises the pressure in their bodies. Nitrogen, a gas in our blood, dissolves under the increased pressure. Nitrogen is physiologically inert, so it is not offered in tconcern metabolism. If the scuba diver ascends to the surchallenge also quickly, the quick drop in pressure decreases the solubility of nitrogen, causing nitrogen bubbles to come out of solution. The nitrogen bubbles have the right to form painful and possibly fatal gas embolisms.

Clinical Significance


Dissolution is necessary for wellness practitioners bereason, for drugs to be took in and have a physiological impact in the humale body, they must be in solution. For solid preparations, such as taballows and suppositories, the price of dissolution affects exactly how fast a drug is took in in the body.


Aqueous solubility is often considered as soon as formulating drugs. Poorly soluble formulations administer obstacles in the advancement of pharmaceuticals. Chloramphenicol, phenytoin, and also digoxin are some examples. Drugs, especially those for dental management, might have poor aqueous solubility. This may bring about low bioavailcapability causing inenough expocertain and also physiologic impact in the body.

Recheck out Questions


Joshi K, Chandra A, Jain K, Talegaonkar S. Nanocrystalization: An Emerging Technology to Enhance the Bioavailcapacity of Poorly Soluble Drugs. Pharm Nanotechnol. 2019;7(4):259-278.
Itai S. . Yakugaku Zasshi. 2019;139(3):419-435.
Karaźniewicz-Łada M, Bąba K, Dolatowski F, Dobrowolska A, Rakicka M. The polymorphism of statins and also its impact on their physicochemical properties. Polim Med. 2018 Jul-Dec;48(2):77-82.
Sujka M, Pankiewicz U, Kowalski R, Nowosad K, Noszczyk-Nowak A. Porous starch and its application in drug shipment devices. Polim Med. 2018 Jan-Jun;48(1):25-29.
Modica de Mohac L, Keating AV, de Fátima Pina M, Raimi-Abraham BT. Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Deliexceptionally. Pharmaceutics. 2018 Dec 24;11(1)
Couillaud BM, Espeau P, Mignet N, Corvis Y. State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation. ChemMedChem. 2019 Jan 08;14(1):8-23.
Ribeiro ACF, Esteso MA. Transport Properties for Pharmaceutical Controlled-Release Systems: A Quick Review of the Importance of Their Study in Biological Solution. Biomolecules. 2018 Dec 17;8(4)

See more: Katy Perry Beach Ball Costume, Katy Perry And Left Shark Couple'S Costume

Radivojev S, Zellnitz S, Paudel A, Fröhlich E. Searching for physiologically appropriate in vitro dissolution approaches for orally inhaled drugs. Int J Pinjury. 2019 Feb 10;556:45-56.
Kadokawa JI. Dissolution, derivatization, and also functionalization of chitin in ionic liquid. Int J Biol Macromol. 2019 Feb 15;123:732-737.